Pard6g Gene Summary [Mouse]

Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be located in bicellular tight junction; cytoplasm; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. Is expressed in several structures, including alimentary system; pharyngo-tympanic tube; skeleton; skin; and submandibular gland primordium. Orthologous to human PARD6G (par-6 family cell polarity regulator gamma). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Pard6g
Official Name
par-6 family cell polarity regulator gamma [Source:MGI Symbol;Acc:MGI:2135606]
Ensembl ID
ENSMUSG00000056214
Bio databases IDs NCBI: 93737 Ensembl: ENSMUSG00000056214
Aliases par-6 family cell polarity regulator gamma
Synonyms 2410049N21Rik, LOC100909590, Par6a, Par6c, PAR6D, par-6 family cell polarity regulator gamma, par-6 family cell polarity regulator γ, PAR-6G, PAR6gamma
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pard6g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Domain present in PSD-95, Dlg, and ZO-1/2
  • canonical PDZ domain
  • protein binding
  • PDZ domain
  • PB1

Pathways

Biological processes and signaling networks where the Pard6g gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • schizophrenia
  • acne
  • osteoarthritis
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pard6g gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of cellular localization
  • cell division
  • centrosome cycle
  • establishment or maintenance of epithelial cell apical/basal polarity
  • establishment or maintenance of cell polarity

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • tight junction
  • occluding junction
  • cell cortex
  • cytosol
  • plasma membrane
  • apical plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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