Chst3 Gene Summary [Mouse]
Enables chondroitin 6-sulfotransferase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process. Acts upstream of or within T cell homeostasis. Is active in Golgi apparatus. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and respiratory system. Used to study schizophrenia. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chst3 |
| Official Name | carbohydrate sulfotransferase 3 [Source:MGI Symbol;Acc:MGI:1858224] |
| Ensembl ID | ENSMUSG00000057337 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 3 |
| Synonyms | C6ST, C6ST-1, carbohydrate sulfotransferase 3, carbohydrate sulphotransferase 3, chondroitin 6 sulphotransferase, GST-0, HSD, LOC102554900 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chst3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proteoglycan sulfotransferase
- chondroitin 6-sulfotransferase
- enzyme
Pathways
Biological processes and signaling networks where the Chst3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- hip osteoarthritis
- osteoarthritis
- spondyloepimetaphyseal dysplasia, omani type
- spine abnormality
- degeneration of lumbar intervertebral disc
- small vessel disease stroke
- Larsen syndrome
- backache
- covid-19 death
regulates
- sulfur-containing compound
role in cell
- number
- proliferation
- quantity
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chst3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- carbohydrate metabolic process
- sulfur compound metabolic process
- N-acetylglucosamine metabolic process
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetylglucosamine 6-O-sulfotransferase activity
- chondroitin 6-sulfotransferase activity
- proteoglycan sulfotransferase activity