H4c3 Gene Summary [Mouse]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | H4c3 |
| Official Name | H4 clustered histone 3 [Source:MGI Symbol;Acc:MGI:2448421] |
| Ensembl ID | ENSMUSG00000060678 |
| Bio databases IDs | |
| Aliases | H4 clustered histone 3 |
| Synonyms | dJ221C16.1, H4-16, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C4, H4C5, H4C6, H4C8, H4C9, H4 clustered histone 3, H4f16, H4FG, H4/g, HIST1H4C, LOC238558, TEBIVANED1, TEVANED1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H4c3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of chromatin
- histone fold domain (HFD) superfamily
- TATA box binding protein associated factor (TAF)
- protein binding
- TATA box binding protein associated factor
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Tessadori-Bicknell-van Haaften neurodevelopmental syndrome 1
- plexiform neurofibroma
- varicocele
- global developmental delay
role in cell
- differentiation
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- cytosol
- chromosome
- nucleosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H4c3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomere organization
- negative regulation of megakaryocyte differentiation
- chromatin organization
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- centromere-specific nucleosome
- chromosome, telomeric region
- nucleus
- extracellular vesicular exosome
- membrane
- macromolecular complex
- extracellular region
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- structural constituent of chromatin
- protein binding
- RNA binding
- protein heterodimerization activity