Blnk Gene Summary [Mouse]
Predicted to enable several functions, including SH2 domain binding activity; enzyme binding activity; and molecular condensate scaffold activity. Involved in positive regulation of gene expression. Located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; liver; and olfactory epithelium. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 4. Orthologous to human BLNK (B cell linker). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Blnk |
| Official Name | B cell linker [Source:MGI Symbol;Acc:MGI:96878] |
| Ensembl ID | ENSMUSG00000061132 |
| Bio databases IDs | |
| Aliases | B cell linker |
| Synonyms | AGM4, BASH, Bca, B-cell linker, BLNK-S, LY57, Lyw-57, SLP-65 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Blnk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- protein kinase binding
- SH2-domain binding
- protein binding activity, bridging
- enzyme binding
- Src homology 2 (SH2) domain
- leucine zipper domain
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor protein
- acidic domain
Pathways
Biological processes and signaling networks where the Blnk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atherosclerosis
- precursor B-cell acute lymphoblastic leukemia
- agammaglobulinemia type 4
- leukemia
- Alzheimer disease
- colorectal adenoma
- colorectal adenoma formation
- rheumatoid arthritis
- hypoplasia
role in cell
- phosphorylation in
- expression in
- apoptosis
- migration
- quantity
- proliferation
- invasion by
- cell cycle progression
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Blnk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- B cell differentiation
- positive regulation of gene expression
- humoral immune response
- transmembrane receptor protein tyrosine kinase signaling pathway
- intracellular signal transduction
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- signaling adaptor activity
- phospholipase binding
- lipid binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- SH2 domain binding
- enzyme binding