Ear6 Gene Summary [Mouse]
Enables RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ear6 |
| Official Name | eosinophil-associated, ribonuclease A family, member 6 [Source:MGI Symbol;Acc:MGI:1890463] |
| Ensembl ID | ENSMUSG00000062148 |
| Bio databases IDs | |
| Aliases | eosinophil-associated, ribonuclease A family, member 6 |
| Synonyms | Ear6, EDN, eosinophil-associated, ribonuclease A family, member 6, Eosinophil-derived neurotoxin, NONSECRETORY RIBONUCLEASE, RAF3, Ribonuclease 2, ribonuclease A family member 2, RNASE U, RNase UpI-2, RNS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ear6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease
- pancreatic ribonuclease
- enzyme
- protein binding
- RNase_A
- lipopolysaccharide binding
Pathways
Biological processes and signaling networks where the Ear6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- ischemic stroke
- heart failure
- primary pulmonary hypertension
- septic shock
- systemic lupus erythematosus
- severe preeclampsia
- severe acute respiratory syndrome
- osteoarthritis
- hypereosinophilia
role in cell
- cell death
- production in
- cell viability
- maturation
- activation
- chemotaxis
- osteogenic differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- lysosome
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ear6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- innate immune response in mucosa
- defense response to Gram-negative bacterium
- induction of bacterial agglutination
- defense response to virus
- defense response to Gram-positive bacterium
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- lyase activity
- ribonuclease activity
- pancreatic ribonuclease activity
- lipopolysaccharide binding