Nrg1 Gene Summary [Mouse]
Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including ERBB signaling pathway; nervous system development; and postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including nervous system development; positive regulation of intracellular signal transduction; and regulation of macromolecule metabolic process. Located in several cellular components, including axon; neuromuscular junction; and plasma membrane. Is active in several cellular components, including GABA-ergic synapse; mossy fiber rosette; and synaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebrovascular disease (multiple); neurodegenerative disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrg1 |
| Official Name | neuregulin 1 [Source:MGI Symbol;Acc:MGI:96083] |
| Ensembl ID | ENSMUSG00000062991 |
| Bio databases IDs | |
| Aliases | neuregulin 1 |
| Synonyms | 6030402G23RIK, AC132407.1, ARIA, D230005F13Rik, GGF, GGFII, GP30, Heregulin, HGL, HRG, HRG1, HRGA, HRGalpha, Hrg α, MST131, MSTP131, NAF, NDF, Ndf44, Neuregulin 1, Nrg1a 44 kda isoform, Nrg1 alpha 2c, NRG1B1, Nrg1 isoform 7, NRG1-IT2, NRG1 SECRETED, Nrg1 α 2c, Nrg alpha, Nrg alpha 2c, Nrg beta, Nrg α, Nrg α 2c, Nrg β, Pro-NRG1, SMDF, Type I Nrg1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemorepellant
- Neuregulin intracellular region
- heparin binding domain
- alpha domain
- cytokine
- growth factor
- EGF_CA
- zinc ion binding
- cytoplasmic domain
- receptor tyrosine kinase binding
- nickel ion binding
- Immunoglobulin like
- intracellular domain
- Neu/ErbB-2 receptor binding
- Immunoglobulin V-set domain
- extracellular domain
- immunoglobulin domain
- Human growth factor-like EGF
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- EGF-like domain
- protein tyrosine kinase activator
- integrin binding
- transmembrane domain
- receptor agonist activity
Pathways
Biological processes and signaling networks where the Nrg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cancer
- neoplasia
- breast cancer
- schizophrenia
- obstructive sleep apnea
- ischemic stroke
- experimental autoimmune encephalomyelitis
- mechanical hypersensitivity
- metabolic syndrome X
phenotypes
- abnormal PNS synaptic transmission
- abnormal atrioventricular cushion morphology
- abnormal cardiovascular system physiology
- abnormal cranial ganglia morphology
- abnormal cranial nerve morphology
- abnormal dorsal root ganglion morphology
- abnormal endplate potential
- abnormal excitatory postsynaptic currents
- abnormal glossopharyngeal nerve morphology
- abnormal heart morphology
- abnormal heart ventricle morphology
- abnormal hypoglossal nerve morphology
- abnormal intercostal muscle morphology
- abnormal iris morphology
- abnormal locomotor coordination
- abnormal mammary gland growth during pregnancy
- abnormal mandibular nerve branching
- abnormal mandibular nerve innervation pattern
- abnormal miniature endplate potential
- abnormal motor neuron innervation pattern
- abnormal myelination
- abnormal myocardium layer morphology
- abnormal nerve conduction
- abnormal neural crest cell migration
- abnormal neuromuscular synapse morphology
- abnormal petrosal ganglion morphology
- abnormal phrenic nerve morphology
- abnormal prepulse inhibition
- abnormal sensory neuron innervation pattern
- abnormal spinal nerve morphology
- abnormal superior vagus ganglion morphology
- abnormal sympathetic ganglion morphology
- abnormal trigeminal ganglion morphology
- abnormal trigeminal nerve morphology
- abnormal vagus nerve morphology
- abnormal ventral spinal root morphology
- absent Schwann cells
- absent mandibular nerve
- absent oligodendrocytes
- absent trabeculae carneae
- absent trigeminal nerve
- centrally nucleated skeletal muscle fibers
- cyanosis
- decreased Schwann cell number
- decreased Schwann cell precursor number
- decreased cardiac muscle contractility
- decreased cardiac output
- decreased heart rate
- decreased heart weight
- decreased left ventricle systolic pressure
- decreased motor neuron number
- decreased muscle spindle number
- decreased radial glial cell number
- decreased sensory neuron number
- decreased ventricle muscle contractility
- defasiculated phrenic nerve
- dilated heart ventricle
- embryonic growth arrest
- embryonic lethality during organogenesis complete penetrance
- enhanced long term potentiation
- enlarged heart
- enlarged pericardium
- failure of atrioventricular cushion closure
- hyperactivity
- increased sensitivity to xenobiotic induced morbidity/mortality
- irregular heartbeat
- limp posture
- mydriasis
- neonatal lethality complete penetrance
- no spontaneous movement
- poor circulation
- preweaning lethality complete penetrance
- preweaning lethality incomplete penetrance
- respiratory failure
- small dorsal root ganglion
- small nodose ganglion
- small petrosal ganglion
- thin diaphragm muscle
- thin ventricular wall
- trabecula carnea hypoplasia
- unresponsive to tactile stimuli
- weight loss
role in cell
- proliferation
- migration
- cell death
- aggregation
- growth
- expression in
- phosphorylation in
- production in
- apoptosis
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basal dendrites
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- postsynaptic region
- membrane surface
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- cisternae
- apical membrane
- presynaptic membrane
- synaptic membrane
- nucleoplasm
- neuromuscular junctions
- neurites
- dendrite initial segments
- synapse
- membrane rafts
- cellular protrusions
- pseudopodia
- perikaryon
- axons
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of transmembrane receptor protein tyrosine kinase activity
- ERBB2-ERBB4 signaling pathway
- negative chemotaxis
- ERBB4-ERBB4 signaling pathway
- cell communication
- positive regulation of cell proliferation
- ERBB2-ERBB3 signaling pathway
- nervous system development
- ERBB4 signaling pathway
- organ development
- negative regulation of secretion
- wound healing
- negative regulation of transcription, DNA-dependent
- ERBB3 signaling pathway
- cardiac muscle cell differentiation
- positive regulation of protein complex assembly
- activation of protein kinase B activity
- intracellular signal transduction
- ERBB signaling pathway
- neural crest cell development
- endocardial cell differentiation
- ventricular trabecula myocardium morphogenesis
- cardiac muscle cell myoblast differentiation
- mammary gland development
- positive regulation of striated muscle cell differentiation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- transcription cofactor activity
- transmembrane receptor protein tyrosine kinase activator activity
- protein tyrosine kinase activator activity
- receptor agonist activity
- ErbB-3 class receptor binding
- integrin binding
- chemorepellent activity
- cytokine activity
- receptor tyrosine kinase binding