Cnnm2 Gene Summary [Mouse]
Enables ATP binding activity and magnesium ion transmembrane transporter activity. Acts upstream of or within magnesium ion transport. Located in basolateral plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and retina. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnnm2 |
| Official Name | cyclin M2 [Source:MGI Symbol;Acc:MGI:2151054] |
| Ensembl ID | ENSMUSG00000064105 |
| Bio databases IDs | |
| Aliases | cyclin M2 |
| Synonyms | ACDP2, Clp2, cyclin and CBS domain divalent metal cation transport mediator 2, cyclin M2, HOMG6, HOMGSMR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnnm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CBS_pair_SF
- Cyclin M transmembrane N-terminal domain
- ATP binding
- magnesium ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- gout
- angina pectoris
- migraines
- schizophrenia
- coronary artery disease
- hypomagnesemia, seizures, and mental retardation 1
- essential hypertension
- myocardial infarction
- renal hypomagnesemia type 6
role in cell
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- basolateral membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnnm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transport
- magnesium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- magnesium ion transmembrane transporter activity