Mir135b Gene Summary [Mouse]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | Mir135b |
| Official Name | microRNA 135b [Source:MGI Symbol;Acc:MGI:3618732] |
| Ensembl ID | ENSMUSG00000065435 |
| Bio databases IDs | |
| Aliases | microRNA 135b |
| Synonyms | hsa-mir-135-1, hsa-mir-135-2, hsa-miR-135a, hsa-mir-135a-1, hsa-mir-135a-2, hsa-miR-135b, microRNA 135, microRNA 135-1, microRNA 135-2, microRNA 135a, microRNA 135a-1, microRNA 135a-2, microRNA 135b, MIR135A, Mir135a01, MIR135A1, MIR135A2, MIR135B, Mirn135, MIRN135-1, MIRN135-2, Mirn135a, MIRN135A1, MIRN135A2, MIRN135B, miRNA-135a mimic, Mmu-mir-135, mmu-miR-135a, mmu-mir-135a-1, mmu-mir-135a-2, mmu-miR-135b, pre-miR135a1, pre-miR135a2, pre-miR135b, rno-miR-135a, rno-miR-135b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mir135b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
- RNA binding
Pathways
Biological processes and signaling networks where the Mir135b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- metastasis
- mammary neoplasm
- seizures
- severe asthma
- metastatic melanoma
- metastatic melanoma cancer
- colorectal adenocarcinoma
- colorectal carcinomagenesis
role in cell
- expression in
- growth
- cell death
- quantity
- activation in
- invasion by
- phosphorylation in
- proliferation
- migration
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm