Muc5b Gene Summary [Mouse]
Acts upstream of or within defense response to bacterium and regulation of macrophage activation. Located in extracellular space. Is expressed in auditory bulla; epithelium; and respiratory system. Human ortholog(s) of this gene implicated in bronchiolitis; idiopathic pulmonary fibrosis; interstitial lung disease 2; and urinary bladder cancer. Orthologous to human MUC5B (mucin 5B, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Muc5b |
| Official Name | mucin 5, subtype B, tracheobronchial [Source:MGI Symbol;Acc:MGI:1921430] |
| Ensembl ID | ENSMUSG00000066108 |
| Bio databases IDs | |
| Aliases | mucin 5, subtype B, tracheobronchial |
| Synonyms | 2300002I04Rik, A130042M24, MG1, MUC5, MUC9, mucin 5b, mucin 5B, oligomeric mucus/gel-forming, mucin 5, subtype B, tracheobronchial, RGD1561983 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Muc5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- Family of unknown function (DUF5585)
- Herpes virus major outer envelope glycoprotein (BLLF1)
- oligomerization domain
- von Willebrand factor type D domain
- peptidase
- protein binding
- C8 domain
- Trypsin Inhibitor like cysteine rich domain
- von Willebrand factor type C domain
- Mucin-2 protein WxxW repeating region
- trypsin inhibitor-like cysteine rich domain
- von Willebrand factor (vWF) type D domain
- Metaviral_G glycoprotein
Pathways
Biological processes and signaling networks where the Muc5b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nasopharyngeal cancer
- epithelial cancer
- chronic obstructive pulmonary disease
- nasopharyngeal carcinoma
- sepsis
- liver cancer
- hepatocellular carcinoma
- androgenic alopecia
- otitis media with effusion
- plaque psoriasis
role in cell
- expression in
- apoptosis
- function
- activation
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- intracellular membrane-bounded organelle
- extracellular vesicles
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Muc5b gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- extracellular matrix
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding