MUC5B
MUC5B Gene Summary
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
Details
| Type | Retained Intron |
| Official Symbol | MUC5B |
| Official Name | mucin 5B, oligomeric mucus/gel-forming [Source:HGNC Symbol;Acc:HGNC:7516] |
| Ensembl ID | ENSG00000117983 |
| Bio databases IDs | |
| Aliases | mucin 5B, oligomeric mucus/gel-forming |
| Synonyms | 2300002I04Rik,A130042M24,MG1,MUC5,MUC9,mucin 5b,mucin 5B, oligomeric mucus/gel-forming,mucin 5, subtype B, tracheobronchial,RGD1561983 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- Family of unknown function (DUF5585)
- Herpes virus major outer envelope glycoprotein (BLLF1)
- oligomerization domain
- von Willebrand factor type D domain
- peptidase
- protein binding
- C8 domain
- Trypsin Inhibitor like cysteine rich domain
- von Willebrand factor type C domain
- Mucin-2 protein WxxW repeating region
- trypsin inhibitor-like cysteine rich domain
- von Willebrand factor (vWF) type D domain
- Metaviral_G glycoprotein
Pathways
Biological processes and signaling networks where the MUC5B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HSPA8
- ITLN2
- CTCF
- KIR2DS2 (includes others)
- ECE2
- LTF
- SNW1
- ESR2
- SP1
- DDX31
disease
- nasopharyngeal cancer
- epithelial cancer
- chronic obstructive pulmonary disease
- nasopharyngeal carcinoma
- sepsis
- liver cancer
- hepatocellular carcinoma
- androgenic alopecia
- otitis media with effusion
- plaque psoriasis
regulated by
- prostaglandin D2
- TNF
- IL13
- IL17A
- KRAS
- lipopolysaccharide
- IGF1
- MLg cells
- IL1B
- CXCL8
regulates
- IL23A
- MUC5B
role in cell
- expression in
- apoptosis
- function
- activation
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- intracellular membrane-bounded organelle
- extracellular vesicles
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MUC5B gene, providing context for its role in the cell.
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- extracellular matrix
- Golgi lumen
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- metal ion binding