Hba-a1 Gene Summary [Mouse]
Predicted to enable several functions, including amyloid-beta binding activity; heme binding activity; and oxygen binding activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to stilbenoid. Acts upstream of or within erythrocyte development; in utero embryonic development; and response to bacterium. Located in myelin sheath. Part of hemoglobin complex. Is expressed in several structures, including blood vessel; early conceptus; hematopoietic system; liver; and visceral pericardium. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA1 (hemoglobin subunit alpha 1) and HBA2 (hemoglobin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hba-a1 |
| Official Name | hemoglobin alpha, adult chain 1 [Source:MGI Symbol;Acc:MGI:96015] |
| Ensembl ID | ENSMUSG00000069919 |
| Bio databases IDs | |
| Aliases | hemoglobin alpha, adult chain 1 |
| Synonyms | Alpha-Globin, alpha GLOBIN 2, ECYT7, Glnc1, GloA, haemoglOBIN alpha 2, haemoglobin, alpha 2, haemoglobin alpha, adult chain 1, haemoglobin alpha, adult chain 2, haemoglobin alpha, adult chain 3, haemoglobin subunit alpha 2, haemoglobin subunit α 2, haemoglOBIN α 2, haemoglobin, α 2, haemoglobin α, adult chain 1, haemoglobin α, adult chain 2, haemoglobin α, adult chain 3, Hba, Hba1, Hba-a1, Hba-a2, Hba-a3, Hbat1, HBA-T2, HBH, HEMOGLOBIN alpha 2, hemoglobin, alpha 2, hemoglobin alpha, adult chain 1, hemoglobin alpha, adult chain 2, hemoglobin alpha, adult chain 3, hemoglobin subunit alpha 2, hemoglobin subunit α 2, hemoglobin α 2, hemoglobin, α 2, hemoglobin α, adult chain 1, hemoglobin α, adult chain 2, hemoglobin α, adult chain 3, α-Globin, α GLOBIN 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hba-A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Globin
- oxygen binding
- peroxidase
- binding protein
- Globin-like protein superfamily
- G-protein-coupled receptor binding
- enzyme
- protein binding
- heme binding
- beta-amyloid binding
Pathways
Biological processes and signaling networks where the Hba-A1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- adenomyosis
- alpha thalassemia
- beta thalassemia
- hemoglobin H hydrops fetalis syndrome
- alpha + thalassemia
- hepatocellular carcinoma
- colorectal cancer
- peripheral arterial disease
role in cell
- expression in
- quantity
- apoptosis
- mean corpuscular volume
- abnormal morphology
- development
- presence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myoendothelial junction
- organelle lumens
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hba-A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oxygen transport
- carbon dioxide transport
- nitric oxide transport
- response to hydrogen peroxide
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- hemoglobin complex
- extracellular space
- extracellular vesicular exosome
- endocytic vesicle lumen
- blood microparticle
- membrane
- haptoglobin-hemoglobin complex
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- peroxidase activity
- protein binding
- iron ion binding
- organic acid binding
- oxygen transporter activity
- heme binding
- haptoglobin binding