Ndufb6 Gene Summary [Mouse]

This gene encodes a subunit of complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain. This complex functions in electron transport and generation of a proton gradient across the inner mitochondrial membrane to drive ATP synthesis. Data from human cell lines suggests that the encoded subunit may be required for electron transfer activity. [provided by RefSeq, Aug 2015]

Details

Type
Protein Coding
Official Symbol
Ndufb6
Official Name
NADH:ubiquinone oxidoreductase subunit B6 [Source:MGI Symbol;Acc:MGI:2684983]
Ensembl ID
ENSMUSG00000071014
Bio databases IDs NCBI: 230075 Ensembl: ENSMUSG00000071014
Aliases NADH:ubiquinone oxidoreductase subunit B6
Synonyms 17 Kda, ci, B17, CI, CI-B17, DD6C4-3, DD6C4-4, Gm137, NADH UBIQUINONE OXIDOREDUCTASE B17, NADH:ubiquinone oxidoreductase subunit B6
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufb6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit
  • NADH2 dehydrogenase
  • enzyme
  • protein binding
  • NADH2 dehydrogenase (ubiquinone)

Pathways

Biological processes and signaling networks where the Ndufb6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Huntington disease
  • acute myeloid leukemia
  • adult acute myeloid leukemia
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • Mitochondria
  • mitochondrial membrane
  • mitochondrial inner membrane
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufb6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • transmembrane transport
  • mitochondrial electron transport, NADH to ubiquinone
  • mitochondrial respiratory chain complex I assembly
  • aerobic respiration
  • mitochondrial ATP synthesis coupled electron transport
  • mitochondrial ATP synthesis coupled proton transport

Cellular Component

Where in the cell the gene product is active
  • mitochondrial membrane
  • respiratory chain complex I
  • mitochondrion
  • mitochondrial inner membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • NADH dehydrogenase (ubiquinone) activity

Gene-Specific Assays for Results You Can Trust

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