Bves Gene Summary [Mouse]
Enables cAMP binding activity. Involved in several processes, including positive regulation of receptor recycling; response to ischemia; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; regulation of heart rate; and sinoatrial node cell development. Located in several cellular components, including bicellular tight junction; lateral plasma membrane; and sarcolemma. Is expressed in several structures, including gut; heart; leg muscle; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to human POPDC1 (popeye domain cAMP effector 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bves |
| Official Name | blood vessel epicardial substance [Source:MGI Symbol;Acc:MGI:1346013] |
| Ensembl ID | ENSMUSG00000071317 |
| Bio databases IDs | |
| Aliases | blood vessel epicardial substance |
| Synonyms | BVES, CARICK, HBVES, LGMD2X, LGMDR25, mBVES, POP1, popeye domain cAMP effector 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bves often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3',5'-cAMP binding
- Popeye protein conserved region
- protein binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- limb-girdle muscular dystrophy type 2X
- limb-girdle muscular dystrophy type 2
- limb-girdle muscular dystrophy
phenotypes
- abnormal skin morphology
- abnormal vocalization
- improved glucose tolerance
- increased bone mineral content
- increased grip strength
- increased lean body mass
- abnormal sinoatrial node conduction
- abnormal sinoatrial node morphology
- altered response of heart to induced stress
- impaired skeletal muscle regeneration
- sinus bradycardia
role in cell
- regeneration
- inhibition in
- differentiation
- recycling in
- transmembrane potential
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cell periphery
- cellular membrane
- Nucleus
- caveolae
- lateral plasma membrane
- sarcolemma
- cytoplasmic vesicles
- tight junctions
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bves gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- epithelial cell-cell adhesion
- cell migration involved in heart development
- hemopoietic progenitor cell differentiation
- positive regulation of locomotion
- sinoatrial node cell development
- muscle organ development
- regulation of heart rate
- heart development
- regulation of membrane potential
- striated muscle cell differentiation
- vesicle-mediated transport
- response to ischemia
- positive regulation of receptor recycling
- vesicle docking
- skeletal muscle tissue development
- regulation of GTPase activity
- substrate adhesion-dependent cell spreading
- regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- caveola
- tight junction
- sarcolemma
- membrane
- cell junction
- cell projection membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- cAMP binding