Nt5c Gene Summary [Mouse]
Enables 5'-nucleotidase activity. Involved in allantoin metabolic process; amide catabolic process; and nucleoside monophosphate catabolic process. Acts upstream of or within deoxyribonucleotide catabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and thymus. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nt5c |
| Official Name | 5',3'-nucleotidase, cytosolic [Source:MGI Symbol;Acc:MGI:1354954] |
| Ensembl ID | ENSMUSG00000020736 |
| Bio databases IDs | |
| Aliases | 5',3'-nucleotidase, cytosolic |
| Synonyms | 5', 3'-nucleotidase, cytosolic, cdN, DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nt5c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 5'-nucleotidase
- nucleotidase
- phosphatase
- pyrimidine nucleotide binding
- identical protein binding
- Haloacid Dehalogenase-like Hydrolases
- 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
Pathways
Biological processes and signaling networks where the Nt5c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nt5c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dTMP catabolic process
- cellular amide catabolic process
- dUMP catabolic process
- dGMP catabolic process
- pyrimidine deoxyribonucleotide catabolic process
- IMP catabolic process
- dephosphorylation
- UMP catabolic process
- dCMP catabolic process
- allantoin metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- 5'-nucleotidase activity
- metal ion binding
- nucleotidase activity
- IMP 5'-nucleotidase activity
- pyrimidine nucleotide binding