Letmd1 Gene Summary [Mouse]
Enables molecular adaptor activity. Involved in mitochondrion organization and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including non-canonical NF-kappaB signal transduction; nucleobase-containing compound biosynthetic process; and toll-like receptor 4 signaling pathway. Located in mitochondrial inner membrane. Is active in nucleus. Is expressed in several structures, including brain; cranial ganglion; dorsal root ganglion; and retina. Orthologous to human LETMD1 (LETM1 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Letmd1 |
| Official Name | LETM1 domain containing 1 [Source:MGI Symbol;Acc:MGI:1915864] |
| Ensembl ID | ENSMUSG00000037353 |
| Bio databases IDs | |
| Aliases | LETM1 domain containing 1 |
| Synonyms | 1110019O13RIK, BB130465, HCCR, HCCR-1, HCCR-2, HCRR1, HCRR-2, LETM1 domain containing 1, MCC-32, Mccr, RGD1310591, SLC55A3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Letmd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LETM1-like, RBD
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- breast cancer
- major depression
role in cell
- phosphorylation in
- expression in
- transmembrane potential
- migration
- phagocytosis by
- generation in
- transformation
- production in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Nucleus
- Mitochondria
- mitochondrial inner membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Letmd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of inflammatory response
- cellular cation homeostasis
- regulation of phagocytosis
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- nucleolus
- mitochondrial outer membrane
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding
- binding, bridging