S100a16 Gene Summary [Mouse]
Enables calcium ion binding activity and identical protein binding activity. Acts upstream of or within response to calcium ion. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; gut; heart; nose; and urinary system. Orthologous to human S100A16 (S100 calcium binding protein A16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100a16 |
| Official Name | S100 calcium binding protein A16 [Source:MGI Symbol;Acc:MGI:1915110] |
| Ensembl ID | ENSMUSG00000074457 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A16 |
| Synonyms | 2300002L21RIK, AAG13, DT1P1A7, S100 calcium binding protein A16, S100F |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse S100a16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- adenoma formation
- aldosterone producing adrenocortical adenoma
- alcoholic liver disease
- hepatic injury
- cervical cancer
role in cell
- expression in
- accumulation in
- phosphorylation in
- quantity
- apoptosis
- proliferation
- molecular cleavage in
- migration
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Extracellular Space
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse S100a16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to calcium ion
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytosol
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- RNA binding
- protein binding
- calcium ion binding
- calcium-dependent protein binding