Rad54b Gene Summary [Mouse]
Predicted to enable DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rad54b |
| Official Name | RAD54 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:3605986] |
| Ensembl ID | ENSMUSG00000078773 |
| Bio databases IDs | |
| Aliases | RAD54 homolog B (S. cerevisiae) |
| Synonyms | E130016E03Rik, Fsbp, LOC100128414, LOC100503583, LOC100506448, RAD54 homolog B, RAD54 homolog B (S. cerevisiae), RDH54, RGD1306507 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad54b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNF2-related domain
- helicase superfamily c-terminal domain
- enzyme
- protein binding
- identical protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- DNA helicase
- DNA translocase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- Class II histone deacetylase complex subunits 2 and 3
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- colon cancer
- cancer
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- colorectal carcinomagenesis
- colon epithelial cancer
- gastrointestinal neoplasia
- colorectal neoplasia
regulates
role in cell
- survival
- function
- abnormal morphology
- DNA damage response
- sensitivity
- recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad54b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- reciprocal meiotic recombination
- determination of adult lifespan
- DNA duplex unwinding
- double-strand break repair via homologous recombination
- response to xenobiotic stimulus
- mitotic recombination
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- DNA helicase activity
- protein binding
- RNA helicase activity
- DNA translocase activity
- hydrolase activity