C7 Gene Summary [Mouse]

Predicted to be involved in complement activation and intracellular sodium ion homeostasis. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
C7
Official Name
complement component 7 [Source:MGI Symbol;Acc:MGI:88235]
Ensembl ID
ENSMUSG00000079105
Bio databases IDs NCBI: 109828 Ensembl: ENSMUSG00000079105
Aliases complement component 7
Synonyms A530026G17, complement C7, complement component 7, Gm1238, LOC103694886
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Thrombospondin type 1 repeats
  • CCP
  • Kazal-type serine protease inhibitor domain
  • membrane-attack complex / perforin
  • MAC/Perforin domain
  • factor I membrane attack complex
  • LDLa
  • Sushi repeat (SCR repeat)
  • SUSHI repeat

Pathways

Biological processes and signaling networks where the C7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • non-small cell lung cancer
  • small cell lung cancer
  • complement component 7 deficiency
  • epithelial cancer
  • prostate cancer
  • diabetic nephropathy
  • Alzheimer disease
  • hepatocellular carcinoma
  • liver cancer
  • colon cancer
regulated by
  • Immunoglobulin
  • C5 CONVERTASE
  • TAFAZZIN
  • CDK4
  • AIM2
  • butyric acid
  • mir-223
  • CCND1
  • methotrexate
  • PIM1
role in cell
  • apoptosis
  • cell death
  • accumulation
  • egression
  • cytolysis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • cell surface
  • cellular membrane
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse C7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • complement activation
  • complement activation, alternative pathway
  • complement activation, classical pathway
  • killing of cells of other organism
  • positive regulation of immune response

Cellular Component

Where in the cell the gene product is active
  • membrane attack complex
  • extracellular space
  • extracellular vesicular exosome
  • extracellular region
  • plasma membrane

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.