C7 Gene Summary [Rat]
Involved in intracellular sodium ion homeostasis. Predicted to be part of membrane attack complex. Biomarker of membranous glomerulonephritis and myocardial infarction. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C7 |
| Official Name | complement C7 [Source:RGD Symbol;Acc:620318] |
| Ensembl ID | ENSRNOG00000061379 |
| Bio databases IDs | |
| Aliases | complement C7 |
| Synonyms | A530026G17, complement C7, complement component 7, Gm1238, LOC103694886 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- CCP
- Kazal-type serine protease inhibitor domain
- membrane-attack complex / perforin
- MAC/Perforin domain
- factor I membrane attack complex
- LDLa
- Sushi repeat (SCR repeat)
- SUSHI repeat
Pathways
Biological processes and signaling networks where the C7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- small cell lung cancer
- complement component 7 deficiency
- epithelial cancer
- prostate cancer
- diabetic nephropathy
- Alzheimer disease
- hepatocellular carcinoma
- liver cancer
- colon cancer
role in cell
- apoptosis
- cell death
- accumulation
- egression
- cytolysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- complement activation, alternative pathway
- complement activation, classical pathway
- killing of cells of other organism
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- membrane attack complex
- extracellular space
- extracellular vesicular exosome
- extracellular region
- plasma membrane