H2-Q1 Gene Summary [Mouse]
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Acts upstream of or within antigen processing and presentation. Predicted to be located in several cellular components, including Golgi apparatus; bounding membrane of organelle; and endoplasmic reticulum exit site. Predicted to be part of MHC class I peptide loading complex; MHC class I protein complex; and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | H2-Q1 |
| Official Name | histocompatibility 2, Q region locus 1 [Source:MGI Symbol;Acc:MGI:95928] |
| Ensembl ID | ENSMUSG00000079507 |
| Bio databases IDs | |
| Aliases | histocompatibility 2, Q region locus 1 |
| Synonyms | 0610037M15Rik, A-28, Aw-24, Aw-33, Aw-34, Aw-66, Aw-68, Aw-69, Aw-74, Aw-80, BE136769, EG667977, ENSMUSG00000121510, Gm10499, Gm11132, Gm8909, gs14-2, H2-B1, H2-Bl, H2-Bl-like, H-2D, H2-D1, H-2DD, H2-Gs10, H2-gs17, H-2K, H2-K1, H-2Kd, H-2K(d), H2-Q1, H2-Q10, H2-Q2, H2-Q4, H2-Q6, H2-Q7, H2-T13, H2-T26, H2-T5, H2-T7, H2-Tw5l, histocompatibility 2, blastocyst, histocompatibility 2, D region locus 1, histocompatibility 2, K1, K region, histocompatibility 2, Q region locus 1, histocompatibility 2, Q region locus 10, histocompatibility 2, Q region locus 2, histocompatibility 2, Q region locus 4, histocompatibility 2, Q region locus 6, histocompatibility 2, Q region locus 7, histocompatibility 2, T region locus 26, HLA-C, HLA class I histocompatibility antigen A-23 alpha chain, HLA class I histocompatibility antigen A-23 α chain, Kb, Kd h chain, K-f, LOC100045864, LOC100133382, LOC100364500, LOC100365191, LOC100507703, LOC100862431, LOC100862447, LOC102554995, LOC102557454, LOC103690108, LOC108167390, LOC108348299, LOC108349031, LOC108349033, LOC56628, LOC636948, LOC684280, LOC687138, major histocompatibility complex, class I, A, MHC 1alpha, MHC-A, Mhc class I q2-k antigen, MHC I, Mhc-i-kd, MumuTL, Ped, predicted gene 10499, Q1, Q10, Q1b, Q1d, Q1k, Q9, Qa-1, Qa10, Qa-2, Qa-4, Qa-6, Qa-7, Qat-4, Qb-1, Qed-1, RT1-A, RT1-A1, RT1-A1n, RT1.A1(N), RT1-A2, RT1-A2n, RT1.A2(N), RT1-CE1, RT1-C/E1, RT1-CE10, RT1-CE12, RT1-CE13, RT1-CE15, RT1-CE16, RT1-CE2, RT1-C/E2, RT1-CE3, RT1-C/E3, RT1-CE4, RT1-C/E4, RT1-CE5, RT1-C/E5, RT1-CE7, RT1-C/E7, RT1.Cg, RT1 class Ia, locus A1, RT1 class Ia, locus A2, RT1 class I, locus1, RT1 class I, locus CE10, RT1 class I, locus CE13, RT1 class I, locus CE15, RT1 class I, locus CE16, RT1 class I, locus CE2, RT1 class I, locus CE3, RT1 class I, locus CE4, RT1 class I, locus CE5, RT1 class I, locus CE7, RT1-E2, rt1-El, RT1-Uav1, RT1-Uc, RT1-Ulv1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-Q1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TAP2 binding
- peptide binding
- MHC class I protein binding
- alpha3 domain
- TAP binding
- TAP1 binding
- TM_EGFR-like
- T-cell receptor binding
- signal peptide
- peptide-binding domain
- alpha2 domain
- identical protein binding
- TAP binding domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- cytoplasmic domain
- CD8 receptor binding
- intracellular domain
- chaperone binding
- extracellular domain
- Immunoglobulin C1-set domain
- immunoglobulin domain
- alpha helix
- protein binding
- receptor binding
- alpha1 domain
- beta-2-microglobulin binding
- binding protein
- MHC_I C-terminus
- transmembrane domain
- protein homodimerization
- receptor agonist activity
- cytosolic tail domain
- peptide antigen binding
Pathways
Biological processes and signaling networks where the H2-Q1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- hepatitis
- metastatic uveal melanoma
- rheumatoid arthritis
- weight gain
- experimental autoimmune encephalomyelitis
- Alzheimer disease
- insulin-dependent diabetes mellitus
- plasma cell myeloma
- breast cancer
role in cell
- activation in
- expression in
- activation
- survival
- binding
- number
- cellular infiltration by
- inhibition
- cytolysis
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- membrane surface
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- plasma membrane extracellular face
- Golgi membrane
- lysosome membrane
- endosomal membrane
- early endosomes
- perinuclear vesicles
- Golgi cisternae
- membrane rafts
- perikaryon
- axons
- dendrites
- presynaptic terminals
- exosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H2-Q1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of CD8-positive, alpha-beta T cell activation
- CD8-positive, alpha-beta T cell activation
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
- protection from natural killer cell mediated cytotoxicity
- immune response
- peptide antigen assembly with MHC class I protein complex
- antigen processing and presentation of exogenous peptide antigen via MHC class I
- innate immune response
- positive regulation of T cell cytokine production
- positive regulation of interferon-gamma production
- T cell mediated cytotoxicity
- T cell mediated cytotoxicity directed against tumor cell target
- positive regulation of CD8-positive, alpha-beta T cell proliferation
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- antibacterial humoral response
- detection of bacterium
- positive regulation of memory T cell activation
- positive regulation of T cell mediated cytotoxicity
- defense response to Gram-positive bacterium
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- MHC class I peptide loading complex
- external side of plasma membrane
- Golgi apparatus
- endoplasmic reticulum
- Golgi membrane
- plasma membrane
- cell surface
- MHC class I protein complex
- Golgi medial cisterna
- early endosome membrane
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- ER to Golgi transport vesicle membrane
- membrane
- phagocytic vesicle membrane
- endoplasmic reticulum exit site
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide antigen binding
- RNA binding
- T cell receptor binding
- beta-2-microglobulin binding
- receptor binding
- CD8 receptor binding
- TAP binding