Srpx Gene Summary [Mouse]
Acts upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in autophagosome and endoplasmic reticulum. Is expressed in several structures, including otic capsule and skeleton. Orthologous to human SRPX (sushi repeat containing protein X-linked). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srpx |
| Official Name | sushi-repeat-containing protein [Source:MGI Symbol;Acc:MGI:1858306] |
| Ensembl ID | ENSMUSG00000090084 |
| Bio databases IDs | |
| Aliases | sushi-repeat-containing protein |
| Synonyms | DRS, DRS-1, DRS-2, ETX1, HEL-S-83p, SRPX1, sushi-repeat-containing protein, sushi repeat containing protein X-linked, sushi-repeat-containing protein, X-linked |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srpx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- Domain of unknown function (DUF4174)
- protein binding
- Sushi repeat (SCR repeat)
- HYR domain
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- epithelial cancer
- Huntington disease
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- apoptosis
- cell viability
- abnormal morphology
- autophagy by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- autophagic vacuoles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srpx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of cell proliferation involved in contact inhibition
- phagolysosome assembly
- autophagy
- cell adhesion
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- membrane
- endoplasmic reticulum
- autophagic vacuole
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent