Crim1 Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; integumental system; and sensory organ. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crim1 |
| Official Name | cysteine rich transmembrane BMP regulator 1 (chordin like) [Source:MGI Symbol;Acc:MGI:1354756] |
| Ensembl ID | ENSMUSG00000024074 |
| Bio databases IDs | |
| Aliases | cysteine rich transmembrane BMP regulator 1 (chordin like) |
| Synonyms | cysteine rich transmembrane BMP regulator 1, S52 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cysteine-rich motor neuron 1 protein C-terminal
- von Willebrand factor type C domain
- insulin-like growth factor receptor
- Insulin-like growth factor binding protein
- Antistasin family
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- chronic obstructive pulmonary disease
- edema
- diabetic nephropathy
- hypoplasia
- syndactyly
- neuroblastoma
- neuroblastoma formation
- Huntington disease
- uterine leiomyoma
- leiomyomatosis
phenotypes
- preweaning lethality complete penetrance
- trunk curl
- abnormal Meckel's cartilage morphology
- abnormal Mullerian duct topology
- abnormal basal lamina morphology
- abnormal ductus venosus valve morphology
- abnormal eye morphology
- abnormal eye posterior chamber morphology
- abnormal glomerular capillary endothelium morphology
- abnormal glomerular capillary morphology
- abnormal glomerular filtration barrier function
- abnormal hepatic portal vein connection
- abnormal hypoglossal nerve topology
- abnormal kidney corticomedullary boundary morphology
- abnormal kidney pelvis morphology
- abnormal optic cup morphology
- abnormal peritubular capillary endothelium morphology
- abnormal peritubular capillary morphology
- abnormal podocyte foot process morphology
- abnormal podocyte morphology
- abnormal renal filtration rate
- abnormal renal glomerulus basement membrane morphology
- abnormal renal glomerulus morphology
- abnormal renin activity
- abnormal rib morphology
- abnormal vertebral arch morphology
- abnormal vertebral artery topology
- abnormal vitelline vein connection
- abnormal vitelline vein topology
- absent connection between subcutaneous lymph vessels and lymph sac
- absent ductus venosus
- absent ductus venosus valve
- absent glomerular endothelium fenestra
- absent mandibular nerve
- absent posterior communicating artery
- absent segment of posterior cerebral artery
- albuminuria
- anal atresia
- anastomosis between internal carotid artery and basilar artery
- aortic arch coarctation
- bleb
- blood in lymph vessels
- cerebral edema
- cortical renal glomerulopathies
- decreased parotid gland size
- decreased podocyte number
- decreased renal glomerular filtration rate
- decreased renal glomerulus basement membrane thickness
- decreased survivor rate
- dilated glomerular capillary
- dilated renal tubules
- dislocated lens
- edema
- fetal bleb
- fragmented Meckel's cartilage
- fused dorsal root ganglion
- fusion of vertebral arches
- glomerulosclerosis
- glomerulus hemorrhage
- hematoma
- herniated liver
- hydronephrosis
- impaired ureteric peristalsis
- increased glomerular capsule space
- increased kidney apoptosis
- increased renal glomerulus basement membrane thickness
- increased vascular permeability
- kidney cortex cysts
- kidney inflammation
- kidney papillary atrophy
- kidney papillary hypoplasia
- lethality incomplete penetrance
- mesangiolysis
- microphthalmia
- muscular ventricular septal defect
- no abnormal phenotype detected
- perimembraneous ventricular septal defect
- perinatal lethality complete penetrance
- perinatal lethality incomplete penetrance
- podocyte foot process effacement
- postnatal lethality complete penetrance
- pulmonary vein hypoplasia
- renal glomerulus cysts
- renal glomerulus hypertrophy
- renal hypoplasia
- renal interstitial fibrosis
- renal tubular necrosis
- retrolental blood
- short kidney papilla
- small kidney
- small lens
- subcutaneous edema
- syndactyly
- telangiectases
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crim1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- nervous system development
- insulin-like growth factor receptor signaling pathway
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- PDZ domain binding
- insulin-like growth factor-activated receptor activity