Crim1 Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; integumental system; and sensory organ. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crim1 |
| Official Name | cysteine rich transmembrane BMP regulator 1 (chordin like) [Source:MGI Symbol;Acc:MGI:1354756] |
| Ensembl ID | ENSMUSG00000024074 |
| Bio databases IDs | |
| Aliases | cysteine rich transmembrane BMP regulator 1 (chordin like) |
| Synonyms | cysteine rich transmembrane BMP regulator 1, S52 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cysteine-rich motor neuron 1 protein C-terminal
- von Willebrand factor type C domain
- insulin-like growth factor receptor
- Insulin-like growth factor binding protein
- Antistasin family
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- edema
- diabetic nephropathy
- hypoplasia
- syndactyly
- neuroblastoma
- neuroblastoma formation
- Huntington disease
- uterine leiomyoma
- leiomyomatosis
regulates
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crim1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- nervous system development
- insulin-like growth factor receptor signaling pathway
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- PDZ domain binding
- insulin-like growth factor-activated receptor activity