Pcdhga12 Gene Summary [Mouse]
Predicted to be involved in cell adhesion. Predicted to act upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell-cell junction and membrane. Is expressed in several structures, including brain; facial prominence; sensory organ; skeleton; and tooth. Orthologous to human PCDHGA12 (protocadherin gamma subfamily A, 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcdhga12 |
| Official Name | protocadherin gamma subfamily A, 12 [Source:MGI Symbol;Acc:MGI:1935229] |
| Ensembl ID | ENSMUSG00000102428 |
| Bio databases IDs | |
| Aliases | protocadherin gamma subfamily A, 12 |
| Synonyms | CDH21, FIB3, pc2c, Pcdh13, PCDH-GAMMA-A12, PCDH-γ-A12, Protocadherin gamma a12, protocadherin gamma subfamily A, 12, Protocadherin γ a12, protocadherin γ subfamily A, 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcdhga12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- Cadherin-like
- Cadherin repeat-like domain
- protein binding
- Cadherin cytoplasmic C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- endometrial adenocarcinoma
role in cell
- quantity
- apoptosis
- survival
- interaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcdhga12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding