Cxcr6 Gene Summary [Mouse]
Enables C-X-C chemokine binding activity and C-X-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human CXCR6 (C-X-C motif chemokine receptor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcr6 |
| Official Name | chemokine (C-X-C motif) receptor 6 [Source:MGI Symbol;Acc:MGI:1934582] |
| Ensembl ID | ENSMUSG00000048521 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) receptor 6 |
| Synonyms | BONZO, CD186, CDw186, C-X-C motif chemokine receptor 6, STRL33, TYMSTR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcr6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-X-C chemokine binding
- C-X-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- coreceptor
Pathways
Biological processes and signaling networks where the Cxcr6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- atherosclerosis
- glioblastoma
- glioblastoma cancer
- COVID-19
- brain cancer
- central nervous system cancer
- head and neck cancer
- head and neck neoplasia
role in cell
- quantity
- trafficking
- replication in
- recognition by
- homing
- fusion
- mobilization in
- persistence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxcr6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- viral genome replication
- calcium-mediated signaling
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- coreceptor activity
- G-protein coupled receptor activity
- C-C chemokine receptor activity
- C-X-C chemokine receptor activity