Smpd2 Gene Summary [Rat]
Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process; intracellular signal transduction; and response to mechanical stimulus. Located in caveola. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smpd2 |
| Official Name | sphingomyelin phosphodiesterase 2 [Source:RGD Symbol;Acc:619753] |
| Ensembl ID | ENSRNOG00000000306 |
| Bio databases IDs | |
| Aliases | sphingomyelin phosphodiesterase 2 |
| Synonyms | ISC1, neutral SMase, Neutral sphingomyelinase, NSMASE, NSMASE1, SMS2, sphingomyelin phosphodiesterase 2, sphingomyelin phosphodiesterase 2, neutral |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smpd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sphingomyelin phosphodiesterase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- enzyme
- protein binding
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the Smpd2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
role in cell
- expression in
- activation in
- formation
- formation in
- apoptosis
- phosphorylation in
- polarization
- growth
- cell death
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- caveolae
- nuclear envelope
- smooth microsomes
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smpd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sphingomyelin metabolic process
- sphingomyelin catabolic process
- ceramide biosynthetic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- caveola
- endoplasmic reticulum
- plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein binding
- sphingomyelin phosphodiesterase activity
- metal ion binding
- phosphoric diester hydrolase activity