Def6 Gene Summary [Rat]
Predicted to be involved in vesicle-mediated transport to the plasma membrane. Predicted to be located in cell-cell junction; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 87. Orthologous to human DEF6 (DEF6 guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Def6 |
| Official Name | DEF6 guanine nucleotide exchange factor [Source:RGD Symbol;Acc:1307945] |
| Ensembl ID | ENSRNOG00000000502 |
| Bio databases IDs | |
| Aliases | DEF6 guanine nucleotide exchange factor |
| Synonyms | 2410003F05Rik, 6430538D02RIK, DEF6 guanine nucleotide exchange factor, differentially expressed in FDCP 6, IBP, IMD87, IRF-Binding, SLAT, Slat2, Slat6, SWAP70L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Def6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- guanyl-nucleotide exchange factor
- nuclear localization sequence
- PH domain
- protein binding
- Pleckstrin homology-like domain
- heptad repeat domain
- Dbl-like domain
- Dbl homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- vasculitis
- diabetic nephropathy
- immunodeficiency 87 and autoimmunity
- experimentally induced rheumatoid arthritis
- hypergammaglobulinemia
- acute disseminated encephalomyelitis
- bone resorption disorder
- neutrophilia
- eosinophilia
role in cell
- expression in
- binding in
- proliferation
- differentiation
- accumulation
- quantity
- formation in
- production in
- migration
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- focal adhesions
- intercellular junctions
- cytosol
- nucleoplasm
- sarcolemma
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Def6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoskeleton
- cytoplasm
- membrane
- filopodium
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity