Amd1 Gene Summary [Rat]
Enables adenosylmethionine decarboxylase activity and putrescine binding activity. Involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amd1 |
| Official Name | adenosylmethionine decarboxylase 1 [Source:RGD Symbol;Acc:2104] |
| Ensembl ID | ENSRNOG00000000585 |
| Bio databases IDs | |
| Aliases | adenosylmethionine decarboxylase 1 |
| Synonyms | adenosylmethionine decarboxylase 1, ADOMETDC, adoMetDC1, AMD, Amd1a, Amd1b, S-ADENOSYLMETHIONINE DECARBOXYLASE, S-adenosylmethionine decarboxylase 1, SAMDC, SAMDC 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Amd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenosylmethionine decarboxylase
- enzyme
- protein binding
- putrescine binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- prostate cancer
- organismal death
- chronic phase chronic myeloid leukemia
- psoriasis
- developmental and epileptic encephalopathy type 87
- blast crisis phase chronic myeloid leukemia
role in cell
- proliferation
- differentiation
- growth
- morphology
- growth in
- invasion
- transformation
- dispersion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Amd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermidine biosynthetic process
- spermine biosynthetic process
- polyamine metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- putrescine binding
- adenosylmethionine decarboxylase activity