Arhgef6 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef6 |
| Official Name | Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:RGD Symbol;Acc:1359674] |
| Ensembl ID | ENSRNOG00000000869 |
| Bio databases IDs | |
| Aliases | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Synonyms | 1600028C08Rik, 1700038J06Rik, 4930592P22RIK, alpha-PIX, COOL2, MRX46, PIXA, Pix-alpha, Pix-α, Rac/Cdc42 guanine nucleotide exchange factor 6, α-PIX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Unstructured region two on RhoGEF 6 and 7
- Calponin homology domain
- leucine zipper domain
- betaPIX coiled coil
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- Src Homology 3 domain superfamily
- RhoGEF
- guanyl-nucleotide exchange factor
- Unstructured region one on RhoGEF 6 and 7
- PH domain
- calponin homology (CH) domain superfamily
- guanine nucleotide exchange factor domain
- Dbl homology domain
- Git1 binding domain
Pathways
Biological processes and signaling networks where the Arhgef6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agrin Interactions at Neuromuscular Junction
- Axonal Guidance Signaling
- Breast Cancer Regulation by Stathmin1
- Cdc42 Signaling
- G Beta Gamma Signaling
- ILK Signaling
- Molecular Mechanisms of Cancer
- PAK Signaling
- Paxillin Signaling
- Reelin Signaling in Neurons
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- survival
- nonsyndromic X-linked mental retardation
- insulin-dependent diabetes mellitus
- X-linked mental retardation
role in cell
- activation in
- apoptosis
- cell death
- function
- proliferation
- binding in
- phosphorylation in
- migration
- number
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Plasma Membrane
- intercellular junctions
- cytosol
- membrane ruffles
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- lamellipodium assembly
- JNK cascade
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity