Arpc1b Gene Summary [Rat]
Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in response to estradiol and response to estrogen. Part of tubulobulbar complex. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arpc1b |
| Official Name | actin related protein 2/3 complex, subunit 1B [Source:RGD Symbol;Acc:2155] |
| Ensembl ID | ENSRNOG00000000991 |
| Bio databases IDs | |
| Aliases | actin related protein 2/3 complex, subunit 1B |
| Synonyms | actin related protein 2/3 complex subunit 1B, actin related protein 2/3 complex, subunit 1B, ARC41, IMD71, L72, p40-ARC, p41-ARC, PLTEID, SOP2Hs |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arpc1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- binding protein
- WD40 repeats
- structural constituent of cytoskeleton
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Arpc1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Phagosome Formation
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- combined immunodeficiency
- platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
- psoriasis
- gastric adenocarcinoma
- gastric epithelial cancer
- infection by Dengue virus 2
role in cell
- expression in
- activation in
- binding in
- formation
- mitosis
- formation in
- loss
- nucleation
- motility
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- podosomes
- actin cytoskeleton
- Nucleus
- centrosome
- cytosol
- plasma membrane projections
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arpc1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- Arp2/3 complex-mediated actin nucleation
- response to estradiol stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- focal adhesion
- actin cytoskeleton
- cytosol
- Arp2/3 protein complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- structural constituent of cytoskeleton