Arpc1b Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Arp2/3 protein complex and tubulobulbar complex. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arpc1b |
| Official Name | actin related protein 2/3 complex, subunit 1B [Source:MGI Symbol;Acc:MGI:1343142] |
| Ensembl ID | ENSMUSG00000029622 |
| Bio databases IDs | |
| Aliases | actin related protein 2/3 complex, subunit 1B |
| Synonyms | actin related protein 2/3 complex subunit 1B, actin related protein 2/3 complex, subunit 1B, ARC41, IMD71, L72, p40-ARC, p41-ARC, PLTEID, SOP2Hs |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arpc1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- binding protein
- WD40 repeats
- structural constituent of cytoskeleton
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Arpc1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- FAK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Phagosome Formation
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- combined immunodeficiency
- platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
- psoriasis
- gastric adenocarcinoma
- gastric epithelial cancer
- infection by Dengue virus 2
phenotypes
- atrophy
- decreased CD4-positive alpha beta T cell number
- decreased KLRG1-positive NK cell number
- decreased Ly6C-positive mature NK cell number
- decreased NK cell number
- decreased bone mineral content
- decreased circulating fructosamine level
- decreased circulating insulin level
- decreased circulating serum albumin level
- decreased circulating triglyceride level
- decreased macrophage cell number
- decreased marginal zone precursor B cell number
- decreased mature NK cell number
- decreased transitional stage T2 B cell number
- fusion of vertebral arches
- glomerulonephritis
- increased CD103-positive CD11b-low dendritic cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD4-positive alpha-beta memory T cell number
- increased KLRG1+ CD4 alpha beta T cell number
- increased KLRG1-positive CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased KLRG1-positive T-helper cell number
- increased circulating calcium level
- increased circulating total protein level
- increased effector memory T-helper cell number
- increased immature NK cell number
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased memory-marker CD4-negative NK T cell number
- increased memory-marker NK cell number
- increased plasma cell number
- inflammation
- process of degenerative change
- vasculitis
- vertebral fusion
- abnormal bone mineralization
- abnormal circulating fructosamine level
- abnormal circulating serum albumin level
- pigment incontinence
- skin fibrosis
role in cell
- expression in
- activation in
- binding in
- formation
- mitosis
- formation in
- loss
- nucleation
- motility
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- podosomes
- actin cytoskeleton
- Nucleus
- centrosome
- cytosol
- plasma membrane projections
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arpc1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- Arp2/3 complex-mediated actin nucleation
- response to estradiol stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- focal adhesion
- actin cytoskeleton
- cytosol
- Arp2/3 protein complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- structural constituent of cytoskeleton