Arpc1a Gene Summary [Rat]
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in muscle cell projection membrane; nucleus; and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arpc1a |
| Official Name | actin related protein 2/3 complex, subunit 1A [Source:RGD Symbol;Acc:620834] |
| Ensembl ID | ENSRNOG00000000996 |
| Bio databases IDs | |
| Aliases | actin related protein 2/3 complex, subunit 1A |
| Synonyms | 0610010H08Rik, 1110030K07Rik, actin related protein 2/3 complex subunit 1A, actin related protein 2/3 complex, subunit 1A, AF070647, Arc40, Arpc1, HEL-68, HEL-S-307, LOC100360680, Sid32, Sid329, SOP2Hs, SOP2L, Sop2p-Like |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arpc1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- actin binding
- WD domain, G-beta repeat
- protein binding
Pathways
Biological processes and signaling networks where the Arpc1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Phagosome Formation
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- actin cytoskeleton
- Nucleus
- cytosol
- plasma membrane projections
- synapse
- cellular protrusions
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arpc1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Arp2/3 complex-mediated actin nucleation
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- extracellular vesicular exosome
- muscle cell projection membrane
- actin cytoskeleton
- cytosol
- Arp2/3 protein complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- actin binding