Tnfrsf13b Gene Summary [Rat]
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf13b |
| Official Name | TNF receptor superfamily member 13B [Source:RGD Symbol;Acc:1595998] |
| Ensembl ID | ENSRNOG00000002304 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 13B |
| Synonyms | 1200009E08Rik, CD267, CVID, CVID2, IGAD2, LOC687262, RYZN, TACI, TNF receptor superfamily member 13B, TNFRSF14B, TRANSMEMBRANE ACTIVATOR and CAML INTERACTOR, tumor necrosis factor receptor superfamily, member 13b, tumour necrosis factor receptor superfamily, member 13b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfrsf13b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cytoplasmic domain
- ectodomain
- transmembrane domain
- intracellular domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
- TACI, cysteine-rich domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Tnfrsf13b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- splenomegaly
- leukemia
- glomerulonephritis
- common variable immunodeficiency type 2
- proteinuria
- common variable immunodeficiency
- common variable immunodeficiency type 1
- major depression
- fibrosis
role in cell
- cell viability
- survival
- apoptosis
- production in
- differentiation
- proliferation
- expression in
- quantity
- number
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell borders
- cellular membrane
- plasma membrane extracellular face
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfrsf13b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of B cell proliferation
- adaptive immune response
- cell surface receptor signaling pathway
- hemopoietic progenitor cell differentiation
- B cell homeostasis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity