Rgl1 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RGL1 (ral guanine nucleotide dissociation stimulator like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgl1 |
| Official Name | ral guanine nucleotide dissociation stimulator,-like 1 [Source:RGD Symbol;Acc:1308947] |
| Ensembl ID | ENSRNOG00000002347 |
| Bio databases IDs | |
| Aliases | ral guanine nucleotide dissociation stimulator,-like 1 |
| Synonyms | LOC100048152, mKIAA0959, Ralgdsl1, ral guanine nucleotide dissociation stimulator like 1, ral guanine nucleotide dissociation stimulator,-like 1, RGL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras-binding domain
- Ral binding domain
- Ubl1_cv_Nsp3_N-like
- Ras/Rap binding domain
- protein binding
- RasGEF
- REM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- attention deficit hyperactivity disorder
- COVID-19
- systemic lupus erythematosus
- colon epithelial cancer
- colon carcinoma
- retinal detachment
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- peripheral arterial disease
- conduct disorder
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity