Mgat5 Gene Summary [Mouse]
Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; integumental system; sensory organ; and urinary system. Orthologous to human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mgat5 |
| Official Name | mannoside acetylglucosaminyltransferase 5 [Source:MGI Symbol;Acc:MGI:894701] |
| Ensembl ID | ENSMUSG00000036155 |
| Bio databases IDs | |
| Aliases | mannoside acetylglucosaminyltransferase 5 |
| Synonyms | 4930471A21RIK, 5330407H02Rik, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, GlcNAc-TV, GNT-V, GNT-VA, LOC100909582, LOC108348294, LOC151162, LOC679424, mannoside acetylglucosaminyltransferase 5, MGAT5A, α-1,6-mannosylglycoprotein 6-β-N-acetylglucosaminyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgat5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
- Glycosyltransferase family 18
- acetylglucosaminyltransferase
- Domain of unknown function (DUF4525)
- enzyme
- manganese ion binding
- glycosyltransferase
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- breast cancer
- epithelial neoplasia
- multiple sclerosis
- chronic lymphocytic leukemia
- dextran sodium sulfate-induced colitis
- adenoma formation
- benign neoplasia
- experimental autoimmune encephalomyelitis
role in cell
- cell viability
- expression in
- proliferation
- binding in
- growth
- invasion by
- production in
- migration
- formation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgat5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- manganese ion binding
- alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity