Cnn2 Gene Summary [Rat]
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within several processes, including cellular response to mechanical stimulus; negative regulation of macrophage migration; and negative regulation of phagocytosis. Predicted to be located in stress fiber. Predicted to be active in actin cytoskeleton. Orthologous to human CNN2 (calponin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnn2 |
| Official Name | calponin 2 [Source:RGD Symbol;Acc:1589807] |
| Ensembl ID | ENSRNOG00000043044 |
| Bio databases IDs | |
| Aliases | calponin 2 |
| Synonyms | Calpo2, calponin 2, H2-calponin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cnn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- actin binding
- Calponin family repeat
- calponin homology (CH) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteosarcoma
- colorectal cancer
- cisplatin-induced acute kidney injury
- age-related macular degeneration
- COVID-19
- acute kidney injury
- osteosarcomagenesis
role in cell
- proliferation
- apoptosis
- cell death
- quantity
- migration
- organization
- number
- function
- abnormal morphology
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- cytoskeleton
- Extracellular Space
- organelle lumens
- intercellular junctions
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cnn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- actomyosin structure organization
- hemopoiesis
- actin filament organization
- wound healing
- regulation of mononuclear cell proliferation
- cellular response to mechanical stimulus
- positive regulation of gene expression
- phagocytosis
- establishment of localization in cell
- regulation of actin filament-based process
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoskeleton
- focal adhesion
- specific granule lumen
- membrane
- stress fiber
- actin cytoskeleton
- extracellular region
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calmodulin binding
- actin binding
- cadherin binding