C4bpa Gene Summary [Rat]
Predicted to enable complement binding activity. Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in acrosomal matrix; cell body; and outer acrosomal membrane. Predicted to be part of zona pellucida receptor complex. Predicted to be active in extracellular space and plasma membrane. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C4bpa |
| Official Name | complement component 4 binding protein, alpha [Source:RGD Symbol;Acc:2235] |
| Ensembl ID | ENSRNOG00000004062 |
| Bio databases IDs | |
| Aliases | complement component 4 binding protein, alpha |
| Synonyms | C4BP, complement component 4 binding protein alpha, complement component 4 binding protein, alpha, complement component 4 binding protein α, complement component 4 binding protein, α, PRP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C4bpa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- protein binding
- Sushi repeat (SCR repeat)
- SUSHI repeat
- Oligomerization domain of C4b-binding protein alpha
Pathways
Biological processes and signaling networks where the C4bpa gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal adenocarcinoma
- epithelial cancer
- liver cancer
- COVID-19
- venous thromboembolism
- Barrett syndrome
- Bell palsy
- complete testicular feminization syndrome
- cleft lip
- thromboembolism
role in cell
- upregulation in
- downregulation in
- agglutination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoplasmic vesicle membrane
- Plasma Membrane
- acrosome
- cytoplasmic vesicles
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C4bpa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of complement activation, classical pathway
- T cell mediated immunity
- complement activation, classical pathway
- innate immune response
- response to symbiotic bacterium
- positive regulation of protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- blood microparticle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding