Akap6 Gene Summary [Rat]
Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and transmembrane transporter binding activity. Involved in several processes, including regulation of intracellular signal transduction; regulation of muscle system process; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including T-tubule; intercalated disc; and junctional sarcoplasmic reticulum membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap6 |
| Official Name | A-kinase anchoring protein 6 [Source:RGD Symbol;Acc:69412] |
| Ensembl ID | ENSRNOG00000004841 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 6 |
| Synonyms | ADAP100, ADAP6, AI482140, AKAP100, Akapalpha, Akapbeta, A-kinase anchoring protein 6, A kinase anchor protein 6, MAKAP, PRKA, PRKA6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akap6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Spectrin repeats
- protein kinase A binding
- adenylate cyclase binding
- protein phosphatase binding
- protein binding activity, bridging
- ion channel binding
- Spectrin repeat
- enzyme binding
- protein binding
- leucine/Isoleucine zipper domain
Pathways
Biological processes and signaling networks where the Akap6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- periodontitis
- diabetes mellitus
- schizophrenia
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- morbid obesity
- overnutrition
- obesity
- prostatic carcinoma
- prostate cancer
role in cell
- growth
- activation in
- hypertrophy
- response by
- disruption in
- action potential
- repolarization
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- sarcoplasmic reticulum
- intercellular junctions
- endoplasmic reticulum membrane
- caveolae
- nuclear envelope
- intercalated disks
- sarcolemma
- Z line
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akap6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- positive regulation of ryanodine-sensitive calcium-release channel activity
- regulation of membrane repolarization
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of release of sequestered calcium ion into cytosol
- protein targeting
- positive regulation of cell growth
- regulation of protein kinase A signaling cascade
- cellular response to cAMP
- positive regulation of calcineurin-NFAT signaling cascade
- cellular response to cytokine stimulus
- regulation of action potential
- positive regulation of cell growth involved in cardiac muscle cell development
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- T-tubule
- caveola
- nuclear membrane
- calcium channel complex
- perinuclear region of cytoplasm
- sarcoplasmic reticulum
- cytoplasm
- intercalated disc
- junctional sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor
- protein kinase A regulatory subunit binding
- adenylate cyclase binding
- ion channel binding
- binding, bridging
- protein kinase A binding