Akap6 Gene Summary [Mouse]

Predicted to enable several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of cation transmembrane transport; positive regulation of protein metabolic process; and regulation of muscle system process. Located in nuclear membrane and perinuclear region of cytoplasm. Is expressed in gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Akap6
Official Name
A kinase (PRKA) anchor protein 6 [Source:MGI Symbol;Acc:MGI:3050566]
Ensembl ID
ENSMUSG00000061603
Bio databases IDs NCBI: 238161 Ensembl: ENSMUSG00000061603
Aliases A kinase (PRKA) anchor protein 6
Synonyms ADAP100, ADAP6, AI482140, AKAP100, Akapalpha, Akapbeta, A-kinase anchoring protein 6, A kinase anchor protein 6, MAKAP, PRKA, PRKA6
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SPEC
  • Spectrin repeats
  • protein kinase A binding
  • adenylate cyclase binding
  • protein phosphatase binding
  • protein binding activity, bridging
  • ion channel binding
  • Spectrin repeat
  • enzyme binding
  • protein binding
  • leucine/Isoleucine zipper domain

Pathways

Biological processes and signaling networks where the Akap6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • periodontitis
  • diabetes mellitus
  • schizophrenia
  • epithelial cancer
  • non-insulin-dependent diabetes mellitus
  • morbid obesity
  • overnutrition
  • obesity
  • prostatic carcinoma
  • prostate cancer
regulated by
regulates
role in cell
  • growth
  • activation in
  • hypertrophy
  • response by
  • disruption in
  • action potential
  • repolarization
  • contraction

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • perinuclear region
  • sarcoplasmic reticulum
  • intercellular junctions
  • endoplasmic reticulum membrane
  • caveolae
  • nuclear envelope
  • intercalated disks
  • sarcolemma
  • Z line
  • transverse tubules

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
  • positive regulation of ryanodine-sensitive calcium-release channel activity
  • regulation of membrane repolarization
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • positive regulation of release of sequestered calcium ion into cytosol
  • protein targeting
  • positive regulation of cell growth
  • regulation of protein kinase A signaling cascade
  • cellular response to cAMP
  • positive regulation of calcineurin-NFAT signaling cascade
  • cellular response to cytokine stimulus
  • regulation of action potential
  • positive regulation of cell growth involved in cardiac muscle cell development

Cellular Component

Where in the cell the gene product is active
  • nuclear envelope
  • T-tubule
  • caveola
  • nuclear membrane
  • calcium channel complex
  • perinuclear region of cytoplasm
  • sarcoplasmic reticulum
  • cytoplasm
  • intercalated disc
  • junctional sarcoplasmic reticulum membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein anchor
  • protein kinase A regulatory subunit binding
  • adenylate cyclase binding
  • ion channel binding
  • binding, bridging
  • protein kinase A binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.