Prdm4 Gene Summary [Rat]
Enables death receptor binding activity. Involved in several processes, including negative regulation of cell growth; regulation of neural precursor cell proliferation; and regulation of stem cell differentiation. Predicted to be located in cytoplasm. Predicted to be part of histone methyltransferase complex. Predicted to be active in nucleus. Orthologous to human PRDM4 (PR/SET domain 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm4 |
| Official Name | PR/SET domain 4 [Source:RGD Symbol;Acc:619929] |
| Ensembl ID | ENSRNOG00000004962 |
| Bio databases IDs | |
| Aliases | PR/SET domain 4 |
| Synonyms | 1700031E19RIK, 2810470D21RIK, PFM1, PR domain containing 4, PR/SET domain 4, SC-1, Schwann cell factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prdm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- death receptor binding
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- nucleic acid binding
- enzyme binding
- protein binding
- PR zinc knuckle motif
- sequence-specific DNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic lymphocytic leukemia
- prostate cancer
- cervical squamous cell carcinoma
- squamous cell cervical cancer
- immunodeficiency
- male pattern hair loss
- tumorigenesis
role in cell
- proliferation
- quantity
- expression in
- invasion by
- growth
- cell cycle progression
- differentiation
- signaling in
- action in
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prdm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell fate commitment
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- histone methyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- methyltransferase activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity