Aph1a Gene Summary [Rat]
Predicted to enable endopeptidase activator activity; enzyme binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including Notch receptor processing; amyloid-beta formation; and proteolysis. Predicted to act upstream of or within metanephros development. Located in early endosome; synaptic membrane; and synaptic vesicle. Is active in presynaptic membrane. Orthologous to human APH1A (aph-1 homolog A, gamma-secretase subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aph1a |
| Official Name | aph-1 homolog A, gamma secretase subunit [Source:RGD Symbol;Acc:1311546] |
| Ensembl ID | ENSRNOG00000023816 |
| Bio databases IDs | |
| Aliases | aph-1 homolog A, gamma secretase subunit |
| Synonyms | 6530402N02Rik, APH-1, Aph-1alpha, aph-1 homolog A, gamma-secretase subunit, aph-1 homolog A, γ-secretase subunit, CGI-78, RGD1311546 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aph1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding activity, bridging
- enzyme binding
- protein binding
- enzyme regulator activity
- Aph-1 protein
- protease activator
Pathways
Biological processes and signaling networks where the Aph1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB4 Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Notch Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- chronic myelomonocytic leukemia
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- Golgi-enriched fraction
- membrane fraction
- mitochondrial fraction
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- presynaptic membrane
- synaptic membrane
- endosomal membrane
- synaptic vesicles
- early endosomes
- microsomal membrane
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aph1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amyloid precursor protein catabolic process
- Notch signaling pathway
- membrane protein ectodomain proteolysis
- metanephros development
- Notch receptor processing
- membrane protein intracellular domain proteolysis
- protein processing
- amyloid precursor protein metabolic process
- positive regulation of endopeptidase activity
- beta-amyloid formation
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synaptic vesicle
- Golgi cisterna membrane
- endoplasmic reticulum
- Golgi membrane
- Golgi apparatus
- plasma membrane
- endoplasmic reticulum membrane
- early endosome
- membrane
- gamma-secretase complex
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- protein binding
- protein binding, bridging
- enzyme binding