Fap Gene Summary [Rat]
Predicted to enable several functions, including integrin binding activity; peptidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including melanocyte apoptotic process; melanocyte proliferation; and negative regulation of cell proliferation involved in contact inhibition. Predicted to be located in several cellular components, including basal part of cell; cell surface; and lamellipodium. Predicted to be part of peptidase complex. Predicted to be active in plasma membrane. Orthologous to human FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fap |
| Official Name | fibroblast activation protein, alpha [Source:RGD Symbol;Acc:621253] |
| Ensembl ID | ENSRNOG00000005679 |
| Bio databases IDs | |
| Aliases | fibroblast activation protein, alpha |
| Synonyms | DPPIV, F19, FAPA, FAPalpha, fibroblast activation protein, fibroblast activation protein alpha, fibroblast activation protein, alpha, fibroblast activation protein α, fibroblast activation protein, α, SIMP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- extracellular domain
- protease binding
- peptidase
- protein binding
- identical protein binding
- Dipeptidyl peptidase IV (DPP IV) N-terminal region
- endopeptidase
- serine endopeptidase
- serine-type peptidase
- integrin binding
- protein homodimerization
- dipeptidyl-peptidase
Pathways
Biological processes and signaling networks where the Fap gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- colorectal cancer
- gastric adenocarcinoma
- neoplasia
- epithelial cancer
- epithelial neoplasia
- prostate cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
role in cell
- expression in
- cell cycle progression
- apoptosis
- migration
- proliferation
- invasion
- invasion by
- organization
- disassembly
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- invadopodia
- cell surface
- Extracellular Space
- apical compartment
- basal compartment
- cellular membrane
- Plasma Membrane
- vesicles
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation involved in contact inhibition
- angiogenesis
- negative regulation of extracellular matrix disassembly
- regulation of fibrinolysis
- proteolysis
- regulation of collagen catabolic process
- cell adhesion
- regulation of cell cycle
- endothelial cell migration
- proteolysis involved in cellular protein catabolic process
- positive regulation of execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- focal adhesion
- apical part of cell
- basal part of cell
- cytoplasm
- membrane
- ruffle membrane
- plasma membrane
- lamellipodium
- lamellipodium membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- serine-type peptidase activity
- endopeptidase activity
- serine-type endopeptidase activity
- integrin binding
- protease binding
- peptidase activity
- dipeptidyl-peptidase activity