Slc4a7 Gene Summary [Rat]
Enables sodium:bicarbonate symporter activity. Predicted to be involved in several processes, including bicarbonate transport; locomotory exploration behavior; and nucleotide biosynthetic process. Predicted to act upstream of or within cochlear nucleus development; eye development; and visual perception. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and stereocilium. Orthologous to human SLC4A7 (solute carrier family 4 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc4a7 |
| Official Name | solute carrier family 4 member 7 [Source:RGD Symbol;Acc:621208] |
| Ensembl ID | ENSRNOG00000005957 |
| Bio databases IDs | |
| Aliases | solute carrier family 4 member 7 |
| Synonyms | E430014N10Rik, NBC2, NBC3, NBCN1, NBCn1-G, SBC2, SLC4A6, SODIUM BICARBONATE COTRANSPORT protein 2, solute carrier family 4 member 7, solute carrier family 4, sodium bicarbonate cotransporter, member 7, Tg(Thy1-SNCA)12Mjff |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc4a7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:bicarbonate symporter
- HCO3- transporter family
- Band 3 cytoplasmic domain
- protein binding
- cytosolic tail domain
- anion exchange protein
- PDZ binding motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- breast carcinoma
- Alzheimer disease
- gastric cancer
- hypertension
- blindness
- productive infection by HIV-1
role in cell
- acidification
- invasion by
- apoptosis
- differentiation
- expression in
- quantity
- growth
- proliferation
- synthesis in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- postsynaptic region
- cellular membrane
- stereocilia
- apical membrane
- basolateral membrane
- cytoplasmic vesicles
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc4a7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inorganic anion transport
- regulation of intracellular pH
- transmembrane transport
- purine nucleotide biosynthetic process
- cellular response to growth factor stimulus
- sodium ion transmembrane transport
- phagosome acidification
- pyrimidine nucleotide biosynthetic process
- bicarbonate transport
- auditory receptor cell development
Cellular Component
Where in the cell the gene product is active
- membrane
- stereocilium
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- anion transmembrane transporter activity
- sodium:bicarbonate symporter activity
- inorganic anion exchanger activity