Ctse Gene Summary [Rat]
Enables aspartic-type endopeptidase activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and protein autoprocessing. Located in endosome. Orthologous to human CTSE (cathepsin E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctse |
| Official Name | cathepsin E [Source:RGD Symbol;Acc:2446] |
| Ensembl ID | ENSRNOG00000006963 |
| Bio databases IDs | |
| Aliases | cathepsin E |
| Synonyms | A430072O03RIK, C920004C08RIK, CATE, CATHEPSIN E, CE, CEA, CEB, Ctsea |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctse often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cathepsin D
- Xylanase inhibitor N-terminal
- A1 Propeptide
- peptidase
- aspartic endopeptidase
- Cellular and retroviral pepsin-like aspartate proteases
- cathepsin E
- identical protein binding
- Eukaryotic aspartyl protease
Pathways
Biological processes and signaling networks where the Ctse gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bladder cancer
- epidermal hyperplasia
- gastric adenocarcinoma
- gastric epithelial cancer
- amyloidosis
- dermatitis
- primary pulmonary hypertension
- alopecia
- streptozotocin induced type1 diabetes
- idiopathic inflammatory myopathy
role in cell
- apoptosis
- proliferation
- migration
- number
- invasion by
- differentiation
- pH
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytoplasmic matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctse gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein autoprocessing
- antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- endosome
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- aspartic-type endopeptidase activity
- peptidase activity