Fnbp1l Gene Summary [Rat]
Predicted to enable GTPase binding activity. Predicted to be involved in several processes, including plasma membrane tubulation; positive regulation of filopodium assembly; and vesicle transport along actin filament. Predicted to act upstream of or within cilium assembly. Predicted to be located in cytoplasmic vesicle and cytosol. Orthologous to human FNBP1L (formin binding protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fnbp1l |
| Official Name | formin binding protein 1-like [Source:RGD Symbol;Acc:1305386] |
| Ensembl ID | ENSRNOG00000013798 |
| Bio databases IDs | |
| Aliases | formin binding protein 1-like |
| Synonyms | 2610318I01Rik, C1ORF39, FLJ20275, formin binding protein 1-like, RGD1305386, TOCA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fnbp1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cdc42 binding domain
- enzyme binding
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- HR1
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Fnbp1l gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Waldenström macroglobulinemia
- cleft lip
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- generation in
- generation
- size
- quantity
- formation
- migration
- invasion by
- formation in
- invasiveness
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- invadopodia
- perinuclear region
- vesicles
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fnbp1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- membrane tubulation
- membrane budding
- cilium morphogenesis
- vesicle organization
- vesicle transport along actin filament
- signal transduction
- autophagy
- positive regulation of filopodium assembly
- membrane invagination
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cell cortex
- cytosol
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase binding
- cadherin binding
- lipid binding