Hpn Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including cochlea morphogenesis; positive regulation of metabolic process; and regulation of epithelial cell proliferation. Predicted to act upstream of or within cholesterol homeostasis; negative regulation of alkaline phosphatase activity; and sensory perception of sound. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; neuronal cell body; and nuclear membrane. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human HPN (hepsin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hpn |
| Official Name | hepsin [Source:RGD Symbol;Acc:61982] |
| Ensembl ID | ENSRNOG00000021097 |
| Bio databases IDs | |
| Aliases | hepsin |
| Synonyms | HEPSIN, Hlb320, TMPRSS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hpn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- Domain of unknown function (DUF1986)
- protein binding
- Scavenger receptor Cys-rich
Pathways
Biological processes and signaling networks where the Hpn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HER2-positive breast cancer
- endometriosis
- hyperglycemia
- diabetes mellitus
- diabetic nephropathy
- HER2 negative hormone receptor negative breast cancer
- luminal B breast cancer
- breast cancer
- hyperlipidemia
role in cell
- proliferation
- expression in
- phosphorylation in
- apoptosis
- growth
- molecular cleavage in
- signaling in
- quantity
- accumulation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- intercellular junctions
- endoplasmic reticulum membrane
- nuclear envelope
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hpn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation by host of viral transcription
- potassium ion transmembrane transport
- cochlea morphogenesis
- pilomotor reflex
- response to thyroid hormone stimulus
- positive regulation of cell growth
- negative regulation of epithelial to mesenchymal transition
- positive regulation of gene expression
- negative regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- proteolysis
- positive regulation of thyroid hormone generation
- positive regulation of plasminogen activation
- basement membrane disassembly
- detection of mechanical stimulus involved in sensory perception of sound
- positive regulation of hepatocyte proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- cell-cell junction
- extracellular vesicular exosome
- membrane
- neuronal cell body
- apical plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type peptidase activity
- serine-type endopeptidase activity
- peptidase activity
- serine-type exopeptidase activity