Mylk2 Gene Summary [Rat]
Enables myosin light chain binding activity and myosin light chain kinase activity. Involved in several processes, including positive regulation of fast-twitch skeletal muscle fiber contraction; regulation of neuronal synaptic plasticity; and synaptic vesicle transport. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mylk2 |
| Official Name | myosin light chain kinase 2 [Source:RGD Symbol;Acc:620934] |
| Ensembl ID | ENSRNOG00000008235 |
| Bio databases IDs | |
| Aliases | myosin light chain kinase 2 |
| Synonyms | 9830004H17Rik, Klmc, KMLC, LOC228785, MLCK, MLCK2, myosin light chain kinase 2, myosin, light polypeptide kinase 2, skeletal muscle, skMLCK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mylk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin light chain kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- calmodulin binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- calmodulin regulated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- myosin binding
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mylk2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- digenic midventricular hypertrophic cardiomyopathy
- Parkinson disease
- hypertrophic cardiomyopathy
- cardiomyopathy
role in cell
- expression in
- activation
- phosphorylation in
- differentiation
- molecular cleavage in
- myogenesis
- synaptic transmission
- sliding
- plasticity
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- dendritic spines
- synaptic vesicles
- myofibrils
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mylk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle cell differentiation
- neuromuscular synaptic transmission
- positive regulation of gene expression
- satellite cell differentiation
- regulation of muscle filament sliding
- protein autophosphorylation
- striated muscle contraction
- cardiac muscle contraction
- peptidyl-threonine phosphorylation
- cardiac muscle tissue morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- synapse
- sarcomere
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- calmodulin-dependent protein kinase activity
- myosin light chain kinase activity
- myosin light chain binding