Vamp7 Gene Summary [Rat]
Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including Golgi vesicle transport; regulated exocytosis; and triglyceride transport. Located in several cellular components, including bounding membrane of organelle; filopodium; and perinuclear region of cytoplasm. Part of SNARE complex. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Orthologous to human VAMP7 (vesicle associated membrane protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vamp7 |
| Official Name | vesicle-associated membrane protein 7 [Source:RGD Symbol;Acc:621558] |
| Ensembl ID | ENSRNOG00000008372 |
| Bio databases IDs | |
| Aliases | vesicle-associated membrane protein 7 |
| Synonyms | SYBL1, TI-VAMP, TI-VAMP7, vesicle-associated membrane protein 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vamp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulated-SNARE-like domain
- SNAP receptor
- cytoplasmic domain
- transmembrane domain
- coiled-coil domain
- protein binding
- SNARE motif
- Longin-like domains
- transporter
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- metastasis
role in cell
- aggregation
- migration
- formation
- activity
- growth
- fusion
- degranulation
- invasion
- exocytosis
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- synaptic vesicle membrane
- pre-chylomicron transport vesicle
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- invadopodia
- cell surface
- cell periphery
- apical compartment
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- secretory granule membrane
- endoplasmic reticulum membrane
- trans Golgi network
- lysosome membrane
- endosomal membrane
- alpha granules
- synaptic vesicles
- neurites
- nerve ending
- synapse
- recycling endosomes
- late endosomes
- transport vesicles
- synaptic-like microvesicles
- azurophil granules
- secretory granules
- pseudopodia
- filopodia
- perikaryon
- clathrin-coated vesicles
- phagosomes
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vamp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- vesicle-mediated transport
- phagocytosis, engulfment
- eosinophil degranulation
- vesicle fusion
- protein transport
- natural killer cell degranulation
- endosome to lysosome transport
- calcium ion-dependent exocytosis
- neutrophil degranulation
- exocytosis
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule
- secretory granule
- phagocytic vesicle
- synapse
- neuron projection
- plasma membrane
- lysosomal membrane
- endoplasmic reticulum membrane
- late endosome membrane
- secretory granule membrane
- trans-Golgi network
- transport vesicle membrane
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- phagocytic vesicle membrane
- SNARE complex
- pseudopodium
- azurophil granule membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding