Nab2 Gene Summary [Rat]
Predicted to enable identical protein binding activity and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including endochondral ossification; negative regulation of transcription by RNA polymerase III; and nervous system development. Predicted to be active in nucleus. Orthologous to human NAB2 (NGFI-A binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nab2 |
| Official Name | Ngfi-A binding protein 2 [Source:RGD Symbol;Acc:1311712] |
| Ensembl ID | ENSRNOG00000008415 |
| Bio databases IDs | |
| Aliases | Ngfi-A binding protein 2 |
| Synonyms | EGR1 binding protein 2, MADER, NGFI-A binding protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ncd1 domain
- transcription regulator
- NCD2 domain
- NAB conserved region 1 (NCD1)
- NAB conserved region 2 (NCD2)
- transcription co-repressor
- nuclear localization sequence
- transcription factor binding
- CHD4-interacting domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- schizophrenia
- insomnia
- tremor
- epidermal hyperplasia
- systemic lupus erythematosus
- hyperkeratosis
role in cell
- differentiation
- migration
- expression in
- activation in
- production in
- proliferation
- number
- tubulation
- sprouting
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Schwann cell differentiation
- negative regulation of transcription from RNA polymerase III promoter
- regulation of epidermis development
- regulation of transcription, DNA-dependent
- endochondral ossification
- myelination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transcription cofactor activity
- protein binding
- transcription corepressor activity
- transcription factor binding