AABR07019383.1 Gene Summary [Rat]
Predicted to enable dopachrome isomerase activity. Predicted to be involved in several processes, including melanin biosynthetic process from tyrosine; positive regulation of neuroblast proliferation; and ventricular zone neuroblast division. Predicted to act upstream of or within cell development; melanin biosynthetic process; and pigmentation. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Predicted to be active in melanosome. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | AABR07019383.1 |
| Official Name | dopachrome tautomerase [Source:NCBI gene;Acc:290484] |
| Ensembl ID | ENSRNOG00000008671 |
| Bio databases IDs | |
| Aliases | dopachrome tautomerase |
| Synonyms | dopachrome tautomerase, DT, LOC102724113, OCA8, RGD1564975, slaty, slt, TRP-2, TYRP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aabr07019383.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dopachrome isomerase
- copper ion binding
- cytoplasmic domain
- Common central domain of tyrosinase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Aabr07019383.1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- oculocutaneous albinism type VIII
- albinism
- androgenic alopecia
- age-related macular degeneration type 7
regulates
- CAV1
- ERK1/2
- DCT
- eumelanin
- melanin
- dopachrome
- 5,6-dihydroxy-2-indolylcarboxylic acid
- phaeomelanin
role in cell
- apoptosis
- proliferation
- cell viability
- synthesis in
- conversion in
- activity
- priming
- development
- melanogenesis
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- filamentous network
- Plasma Membrane
- cytosol
- trans Golgi network
- melanosomes
- melanosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aabr07019383.1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- developmental pigmentation
- ventricular zone neuroblast division
- epidermis development
- positive regulation of neuroblast proliferation
- melanin biosynthetic process from tyrosine
- cell development
- response to blue light
Cellular Component
Where in the cell the gene product is active
- melanosome membrane
- melanosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- oxidoreductase activity
- dopachrome isomerase activity