Epx Gene Summary [Rat]
Predicted to enable peroxidase activity. Predicted to be involved in defense response to bacterium. Predicted to act upstream of or within defense response to nematode; eosinophil migration; and regulation of cytokine production. Predicted to be active in extracellular space. Orthologous to human EPX (eosinophil peroxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epx |
| Official Name | eosinophil peroxidase [Source:RGD Symbol;Acc:1311882] |
| Ensembl ID | ENSRNOG00000008707 |
| Bio databases IDs | |
| Aliases | eosinophil peroxidase |
| Synonyms | eosinophil peroxidase, EPER, EPO, EPP, EPXD, EPX-PEN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxidase
- Animal haem peroxidase
- enzyme
- Animal heme peroxidases and related proteins
Pathways
Biological processes and signaling networks where the Epx gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eosinophil peroxidase deficiency
- colitis
- asthma
role in cell
- activation
- cell death
- abnormal morphology
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- granules
- granule matrix
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- defense response to nematode
- negative regulation of interleukin-5 production
- negative regulation of interleukin-10 production
- negative regulation of macrophage cytokine production
- eosinophil migration
- defense response to bacterium
- positive regulation of interleukin-4 production
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- metal ion binding
- heme binding